mainly used as cancer chemotherapy and in sickle cell anemia to increase the production of fetal hemoglobin
the dose of sickle cell anemia is 10-20 mg /kg/ day starting with 10 mg/kg/day and then to
side effects
drowsiness headache hallucitaion seizures nausea vomittinmg stomatitis mucosititis myelosuppression (onset day 7 ,nadir day 10 recovery day 21 ) .
alopecia,maculopapular rash dry skin erythema of the face and hands hepatitis increase urea nitrogen and serum creatinine hyperuricemia
patient prediction for treatment of hydroxyurea
a-patietnt more than 7 yr of age
b-to start hyroxyurea on admission to hospital
c-the case to be discussed in the morning pediatric clinical meeting (board decision) and the indices of sickle cell diease severity specified
d-indcies of severity include 2 attcks or more of acute chest syndrome and /or one attack of and one attck or more of acute chest syndrome or 2 attacks of CVA or any disease entity requiring exhange transfusion and /or ICU admission and incapacitating VOC -councelling with parents and /or the patients if more than 10 yr about the drug and mention some of the possible side effects and value of consent -
e-OPD folllow up on monthly basis to assess weight height pubertal development CBC including TLC and ANC LFTs Hb electrophoresis and esp for hb F.-note increased fetal Hb and reduction of leucocytic count to low normal and increase of MCV of over 100 fl / dl indicate compliance and effeciveness of hysdroxyurea
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